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Thisresults in enlargement ofthe alveolar capillaries and small hemorrhagesinto the alveoli. Children with SCD are also at risk of avascular necrosis of thefemoral head, which should also be excluded as a diagnosis
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The single remaining variation wasa missense in the highly conserved DNA-binding “paired box” domain of PAX1,which impairs the transcriptional activity of PAX1. These premises lead to the deduction that some diseases can undermineswallowing and phonation.
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